N-SUBSTITUTED 4-CARBOXY-1-PHENYL-1H-PYRAZOLE-5-PROPANAMIDES WITH ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND PLATELET ANTIAGGREGATING ACTIVITIES

Authors
MENOZZI G MOSTI L SCHENONE P DAMICO M FALZARANO C ROSSI F
Citation
G. Menozzi et al., N-SUBSTITUTED 4-CARBOXY-1-PHENYL-1H-PYRAZOLE-5-PROPANAMIDES WITH ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND PLATELET ANTIAGGREGATING ACTIVITIES, Il Farmaco, 48(4), 1993, pp. 539-549
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
4
Year of publication
1993
Pages
539 - 549
Database
ISI
SICI code
0014-827X(1993)48:4<539:N4WA>2.0.ZU;2-4
Abstract
The synthesis of a series of N-substituted 4-carboxy-1-phenyl-1H-pyraz ole-5-propanamides by reaction of 1-phenyl-1H-oxepino[4,3-c]pyrazole-4 (8H), 6(7H)-dione with aromatic primary amines is described. Some amid es showed a platelet antiaggregating activity in vitro superior or com parable to that of acetylsalicylic acid, as well as moderate antiinfla mmatory, analgesic and antipyretic activities in rats or mice.