LOCAL CUTANEOUS REACTION INDUCED BY SUBCUTANEOUS INTERLEUKIN-2 AND INTERFERON ALPHA-2A IMMUNOTHERAPY FOLLOWING ABMT

Authors
KLAPHOLZ L ACKERSTEIN A GOLDENHERSH MA VARDY D NAGLER A
Citation
L. Klapholz et al., LOCAL CUTANEOUS REACTION INDUCED BY SUBCUTANEOUS INTERLEUKIN-2 AND INTERFERON ALPHA-2A IMMUNOTHERAPY FOLLOWING ABMT, Bone marrow transplantation, 11(6), 1993, pp. 443-446
Citations number
19
Categorie Soggetti
Hematology,Oncology,Immunology
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
11
Issue
6
Year of publication
1993
Pages
443 - 446
Database
ISI
SICI code
0268-3369(1993)11:6<443:LCRIBS>2.0.ZU;2-F
Abstract
Immunotherapy using subcutaneous injections of recombinant interleukin -2 (IL-2) and recombinant interferon alpha-2a (IFN-alpha) for advanced hematologic and solid tumors is rapidly developing. We report five pa tients with Hodgkin's and non-Hodgkin's lymphoma who developed a local cutaneous reaction consisting of inflammatory painful nodules with a central multiloculated vesicle at the site of sc injections of IL-2 an d IFN-alpha immunotherapy following ABMT. This is the first report of a local cutaneous adverse reaction induced by IL-2 and IFN-alpha immun otherapy following ABMT.