DIFFERENTIAL PATTERN OF BETA-AMYLOID PROTEIN DEPOSITION WITHIN CORTICAL SULCI AND GYRI IN ALZHEIMERS-DISEASE

We have quantified the pattern of beta-amyloid protein (betaAP) deposi tion in the sulci and gyri of the frontal cortex in Alzheimer's diseas e. The distribution pattern in the frontal cortex gyri is unequivocall y different from the pattern found in the frontal sulci. These finding s, in conjunction with our previous studies, reflect a differential vu lnerability between the sulci and the gyri with respect to Alzheimer's disease pathology, sulci being affected to a greater extent. It is pr obable that the different patterns of deposition relate to the underly ing cytoarchitecture of the cortex.