BIOLOGICAL EFFECTS OF DRUG-LOADED BIODEGRADABLE MEMBRANES FOR GUIDED BONE REGENERATION

The biological effects of drug-loaded biodegradable novel membrane for guided bone regeneration (GBR) was evaluated. The membranes were poly glycolic acid mesh coated with poly-L-lactic acid containing flurbipro fen, tetracycline or PDGF-BB. Porous structure was generated in the me mbranes by using a phase inversion method. The membrane was less toxic , nicely biodegradable and biocompatible for 8 wk after implantation i n the dorsal skin of the rat. The drugs released from the membranes we re shown to be effective for new bone formation. Tetracycline, flurbip rofen or PDGF-BB loaded membrane was markedly effective for osteoid ti ssue and new bone formation in the bony defect prepared in rat calvari a to compare with that by unloaded membrane. These results suggested t hat drug-loaded biodegradable barrier membrane might be a potential to ol for GBR in periodontal therapy.