PRIMING STIMULATION FACILITATES HEBB-TYPE PLASTICITY IN THE SCHAFFER COLLATERAL-COMMISSURAL PATHWAYS OF THE MOUSE HIPPOCAMPUS

Authors
FEDOROV NB SERGEEVA OA SKREBITSKY VG
Citation
Nb. Fedorov et al., PRIMING STIMULATION FACILITATES HEBB-TYPE PLASTICITY IN THE SCHAFFER COLLATERAL-COMMISSURAL PATHWAYS OF THE MOUSE HIPPOCAMPUS, Experimental Brain Research, 94(2), 1993, pp. 270-272
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Experimental Brain Research → ACNP
ISSN journal
00144819
Volume
94
Issue
2
Year of publication
1993
Pages
270 - 272
Database
ISI
SICI code
0014-4819(1993)94:2<270:PSFHPI>2.0.ZU;2-Y
Abstract
Hebb-type plastic changes of synaptic trans mission were analyzed in t he Schaffer collateral-commissural pathways (SC) of the mouse hippocam pal slice. Low frequency (0.05-0.1 Hz) SC stimulation (S2) was paired with intracellular depolarization (100-200 ms; 2-3 nA) of CA1 pyramida l. Postpairing facilitation of synaptic responses in picrotoxin-free m edium occurred only when S2 was ''primed'' with neurons the preceding shock (S1) administered through the same electrode 200 ms before S2. P riming-determined disinhibition in local circuitry is supposed to be r esponsible for this phenomenon.