GAS-CHROMATOGRAPHY MASS-SPECTROMETRIC ANALYSIS OF URINARY NUCLEOSIDESIN CANCER-PATIENTS - POTENTIAL OF MODIFIED NUCLEOSIDES AS TUMOR-MARKERS

Authors
LANGRIDGE JI MCCLURE TD ELSHAKAWI S FIELDING A SCHRAM KH NEWTON RP
Citation
Ji. Langridge et al., GAS-CHROMATOGRAPHY MASS-SPECTROMETRIC ANALYSIS OF URINARY NUCLEOSIDESIN CANCER-PATIENTS - POTENTIAL OF MODIFIED NUCLEOSIDES AS TUMOR-MARKERS, Rapid communications in mass spectrometry, 7(6), 1993, pp. 427-434
Citations number
28
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
7
Issue
6
Year of publication
1993
Pages
427 - 434
Database
ISI
SICI code
0951-4198(1993)7:6<427:GMAOUN>2.0.ZU;2-0
Abstract
Analysis of urine from cancer patients by capillary gas chromatography /mass spectrometry positively identified 14 urinary nucleosides includ ing several modified nucleosides. Levels of the modified nucleosides 1 -methyladenosine, 2-methylguanosine, N2,N2-dimethylguanosine and 1-met hylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N2,N2-dimethy lguanosine were found to correlate with the stage of the cancer.