C. Paradisi et al., COLLISIONAL ION ACTIVATION IN THE ION-TRAP BY A 3-STEP TICKLE FUNCTION, Rapid communications in mass spectrometry, 7(6), 1993, pp. 440-445
The effects of performing ion resonance collisional activation in two
steps separated by an intermediate phase were studied. The results sho
w that the time duration and the tickle frequency setting used in this
intermediate stage determine the phase of the tickle output in the se
cond activation stage which ft is essential to control, to ensure the
efficiency of the activation process. The following interpretation is
offered: the activation process can be efficiently resumed after a per
iod of interruption, provided the tickle voltage in the second activat
ion step is in-phase with the axial motion of the ions induced by the
tickle field during the first activation stage.