ANALYSIS OF THE SQUALESTATINS BY ONLINE PACKED CAPILLARY LIQUID-CHROMATOGRAPHY DYNAMIC LIQUID SECONDARY-ION MASS-SPECTROMETRY

Authors
LANE SJ BRINDED KA TAYLOR NL
Citation
Sj. Lane et al., ANALYSIS OF THE SQUALESTATINS BY ONLINE PACKED CAPILLARY LIQUID-CHROMATOGRAPHY DYNAMIC LIQUID SECONDARY-ION MASS-SPECTROMETRY, Rapid communications in mass spectrometry, 7(6), 1993, pp. 492-495
Citations number
12
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
7
Issue
6
Year of publication
1993
Pages
492 - 495
Database
ISI
SICI code
0951-4198(1993)7:6<492:AOTSBO>2.0.ZU;2-6
Abstract
A mixture of four squalestatins was separated and characterized by gra dient-packed capillary liquid chromatography combined with dynamic liq uid secondary-ion mass spectrometry (LSIMS). Thioglycerol/glycerol mat rix was added post-column. Negative-ion LSIMS was found to afford spec tra typified by strong molecular ions with structurally informative fr agments. The new method showed improvements in sensitivity and specifi city for this class of compound when compared to existing thermospray methods.