IRON(III) CHLORIDE INJECTION INCREASES NIGRAL URIC-ACID IN GUINEA-PIG

Authors
WARD VL MCGINTY JF CHURCH WH
Citation
Vl. Ward et al., IRON(III) CHLORIDE INJECTION INCREASES NIGRAL URIC-ACID IN GUINEA-PIG, NeuroReport, 4(6), 1993, pp. 787-790
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
4
Issue
6
Year of publication
1993
Pages
787 - 790
Database
ISI
SICI code
0959-4965(1993)4:6<787:ICIINU>2.0.ZU;2-N
Abstract
THE present study was carried out to determine if iron chloride (FeCl3 ) injections into the substantia nigra of guinea-pigs produced changes in nigro-striatal uric acid levels. Two-weeks following unilateral in jection of FeCl3 (185 nmol Fe3+), ipsilateral uric acid levels were in creased 176% over contralateral levels in the substantia nigra. No eff ect on striatal uric acid levels was observed. Iron chloride injection produced a 74% depletion of dopamine levels in the ipsilateral striat um. Ipsilateral/contralateral ratios were significantly decreased for striatal dopamine and significantly increased for nigral uric acid whe n compared with saline-injected controls. The results of this work ind icate that FeCl3 injections into the substantia nigra of guinea-pigs p roduce a significant, localized increase in tissue uric acid levels tw o weeks after treatment.