Recent advances in the molecular biology of hepatitis B virus. Recent
advances in molecular biology had led to a better understanding of the
pathology of hepatitis B virus. The polymerase chain reaction techniq
ue has shown that the genome of hepatitis B virus is highly variable.
Mutations in the pre-core region are associated with HBe Ag negative c
hronic hepatitis and fulminant hepatitis B moreover, HBV vaccine induc
e mutations within the S gene and escape mutant of hepatitis B virus i
n immunized patients. The aim of this paper is to assess the clinical,
serological and therapeutic features of hepatitis B variants.