THE HUMAN TRANSCRIPTIONAL ADAPTER GENES TADA2L AND GCN5L2 COLOCALIZE TO CHROMOSOME 17Q12-Q21 AND DISPLAY A SIMILAR TISSUE EXPRESSION PATTERN

The chromosomal locations and the tissue expression patterns of the hu man transcriptional adaptors TADA2L and GCN5L2 have been determined. N orthern blot analysis across a range of human tissues revealed that bo th the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most tissue types, the genes are ex pressed at relatively similar levels, suggesting coordinated regulatio n of TADA2L and GCN5L2 transcription. Chromosomal mapping by fluoresce nce in situ hybridization indicated that these genes reside near each other on chromosome 17; TADA2L mapped within bands 17q12-q21, while GC N5L2 mapped distally within band 17q21. (C) 1997 Academic Press.