CORTICAL SPREADING DEPRESSION DOES NOT RESULT IN THE RELEASE OF CALCITONIN GENE-RELATED PEPTIDE INTO THE EXTERNAL JUGULAR-VEIN OF THE CAT -RELEVANCE TO HUMAN MIGRAINE
Rd. Piper et al., CORTICAL SPREADING DEPRESSION DOES NOT RESULT IN THE RELEASE OF CALCITONIN GENE-RELATED PEPTIDE INTO THE EXTERNAL JUGULAR-VEIN OF THE CAT -RELEVANCE TO HUMAN MIGRAINE, Cephalalgia, 13(3), 1993, pp. 180-183
There is circumstantial evidence that cortical spreading depression (S
D) may account for the scotoma and the ''spreading cortical oligemia''
seen during migraine with aura. It has been shown that calcitonin gen
e-related peptide (CGRP) is increased in blood taken from the external
jugular vein (EJV) in humans during migraine and after stimulation of
the trigeminal ganglion. To test the hypothesis that cortical SD may
elevate the concentration of this vasoactive peptide in the EJV during
migraine, we have measured its concentration in the external jugular
vein of cats during cortical SD. This study demonstrates that SD has n
o effect on the concentration of CGRP either during the passage of a w
ave of spreading depression across the cortex or, 60 min later, during
the period of post-SD cortical oligemia.