PIGMENTED GANGLIONEUROBLASTOMA - A TUMOR-CELL STORAGE DISEASE

Authors
ODOWD GM GAFFNEY EF
Citation
Gm. Odowd et Ef. Gaffney, PIGMENTED GANGLIONEUROBLASTOMA - A TUMOR-CELL STORAGE DISEASE, Histopathology, 22(6), 1993, pp. 591-593
Citations number
6
Categorie Soggetti
Cytology & Histology",Pathology
Journal title
Histopathology → ACNP
ISSN journal
03090167
Volume
22
Issue
6
Year of publication
1993
Pages
591 - 593
Database
ISI
SICI code
0309-0167(1993)22:6<591:PG-ATS>2.0.ZU;2-S
Abstract
We report a composite nodular ganglioneuroblastoma, distinctive for th e presence of coarsely granular black intracellular pigment, which was histochemically indistinguishable from melanin. Ultrastructurally, th e pigment was resolved as numerous heterogeneous lysosomes, containing material compatible with oxidized lipid residues, the accumulation of which may reflect acquired lysosomal dysfunction in individual tumour cells-a tumour cell 'storage disease'.