A MICROSATELLITE POLYMORPHISM IN THE HUMAN INSULIN-RECEPTOR GENE - A HIGHLY INFORMATIVE MARKER FOR LINKAGE ANALYSIS

Authors
IKEGAMI H FUKUDA M KAWAGUCHI Y FUJIOKA Y UEDA H OGIHARA T
Citation
H. Ikegami et al., A MICROSATELLITE POLYMORPHISM IN THE HUMAN INSULIN-RECEPTOR GENE - A HIGHLY INFORMATIVE MARKER FOR LINKAGE ANALYSIS, Diabetes research and clinical practice, 20(1), 1993, pp. 7-10
Citations number
12
Categorie Soggetti
Gastroenterology & Hepatology","Endocrynology & Metabolism
Journal title
Diabetes research and clinical practice → ACNP
ISSN journal
01688227
Volume
20
Issue
1
Year of publication
1993
Pages
7 - 10
Database
ISI
SICI code
0168-8227(1993)20:1<7:AMPITH>2.0.ZU;2-V
Abstract
To study genetic susceptibility to non-insulin dependent diabetes mell itus (NIDDM), association of insulin receptor gene, a candidate gene f or NIDDM, with NIDDM was studied. A microsatellite polymorphism locate d in intron 2 of the human insulin receptor gene was detected by the p olymerase chain reaction and used as a genetic marker. Eight different alleles were observed, indicating highly polymorphic nature of this m arker. Although no association of this marker with NIDDM was observed in Japanese subjects, this marker will be useful for linkage studies o f insulin receptor gene and genes located close to this gene on chromo some 19.