T. Torisu et al., ASSOCIATION OF HLA-DR AND HLA-DQ ANTIGENS WITH CONGENITAL DISLOCATIONAND DYSPLASTIC OSTEOARTHRITIS OF THE HIP JOINTS IN JAPANESE PEOPLE, Arthritis and rheumatism, 36(6), 1993, pp. 815-818
Objective. To investigate the frequency of HLA-DR and DQ antigens amon
g patients with congenital dislocation of the hip joint or dysplastic
osteoarthritis (OA) and to determine whether tissue typing might contr
ibute to better understanding of these disorders. Methods. HLA-DR and
DQ typing was undertaken in 18 patients with congenital dislocation of
the hip joints, 65 patients with dysplastic OA of the hip, 42 patient
s with primary OA of the knee, and 40 normal controls. Typing for HLA-
D antigens was performed using the standard microlymphocytotoxicity me
thod. Results. The frequency of HLA-DR4 in patients with congenital di
slocation of the hip joint (61.1%) and patients with dysplastic OA of
the hip (58.5%) was significantly increased compared with normal contr
ols (27.5%) (P(corr) < 0.05 and P < 0.01, respectively). The relative
risk for HLA-DR4 was 4.1428 and 3.7104, respectively, in these 2 disea
se groups. The frequency of HLA-DR4 in the patients with primary OA of
the knee (35.7%) did not differ significantly from that in normal con
trols. Conclusion. The results strongly indicate that development of c
ongenital dislocation of the hip joint and progression of dysplastic O
A of the hip are associated with genes of the HLA-D region.