RAPID DETECTION OF CHINESE G-GAMMA-GAMMA-DELTA-BETA)O-THALASSEMIA BY POLYMERASE CHAIN-REACTION((A)

Authors
KO TM TSENG LH HSIEH FJ CHUANG SM LEE TY
Citation
Tm. Ko et al., RAPID DETECTION OF CHINESE G-GAMMA-GAMMA-DELTA-BETA)O-THALASSEMIA BY POLYMERASE CHAIN-REACTION((A), Acta haematologica, 89(2), 1993, pp. 80-81
Citations number
8
Categorie Soggetti
Hematology
Journal title
Acta haematologica → ACNP
ISSN journal
00015792
Volume
89
Issue
2
Year of publication
1993
Pages
80 - 81
Database
ISI
SICI code
0001-5792(1993)89:2<80:RDOCGB>2.0.ZU;2-Z
Abstract
The Chinese G(gamma+)(A(gamma)deltabeta)-degrees-thalassemia is caused by a deletion of more than 80 kilobases. It has a beta+-thalassemia p henotype and should be differentiated from other mutations causing bet a-thalassemia. Using polymerase chain reaction with three oligonucleot ide primers bridging the breakpoints, the deletion can be detected eas ily. The method is useful in the genetic counseling and prenatal diagn osis of the at-risk families.