Theoretical and empirical research suggests psychosocial functioning i
s important in drug abuse intervention strategies, especially those fo
cusing on efforts to change AIDS risk behaviors. Self-esteem, depressi
on, anxiety, proneness to risk taking, decision-making confidence, sel
f-assessment of drug use problems, and desire for help with drug probl
ems, along with personal background and health history indicators, wer
e assessed for 194 injection drug users in an AIDS prevention outreach
program in New Orleans. Composite index scores for needle risk behavi
ors were associated with low self-esteem and low decision-making confi
dence as well as with higher scores on depression, anxiety, drug use p
roblems, and desire for help. However, these psychosocial measures wer
e not significantly related to the composite index for sex risks. Heal
th history measures, represented by previous exposures to hepatitis an
d sexually transmitted diseases, were significantly related to both ne
edle and sex risk indices. Implications for AIDS intervention efforts
are discussed.