Ke. Towbin et al., CONCEPTUALIZING BORDERLINE SYNDROME OF CHILDHOOD AND CHILDHOOD SCHIZOPHRENIA AS A DEVELOPMENTAL DISORDER, Journal of the American Academy of Child and Adolescent Psychiatry, 32(4), 1993, pp. 775-782
Objective: This is the first attempt to define and validate criteria f
or an early onset, chronic syndrome of disturbances in affect modulati
on, social relatedness, and thinking. This study formulates and tests
five hypotheses that follow from conceptualizing this syndrome as a de
velopmental disorder. The advantages of viewing this syndrome as a dev
elopmental disorder are discussed and compared with alternative formul
ations such as childhood schizophrenia or borderline syndrome of child
hood. Method: An inpatient cohort (26 boys, 4 girls) was ascertained u
sing specific, defined criteria. Using standardized measures on retros
pective chart reviews, these subjects were compared with two different
inpatient samples: one diagnosed with dysthymic disorder, the other w
ith conduct disorder. Results: The criteria readily distinguished betw
een developmentally disordered children and comparison groups. Finding
s also supported the hypotheses in the predicted directions; index sub
jects had earlier onset of symptoms, poorer social and overall adjustm
ent, longer hospitalizations, and poorer outcomes. Conclusions: Findin
gs support the validity of this developmental concept for a multiple c
omplex developmental disorder and give preliminary, ''first-cut'' vali
dity to these specified criteria.