Pa. Flordal et S. Sahlin, USE OF DESMOPRESSIN TO PREVENT BLEEDING COMPLICATIONS IN PATIENTS TREATED WITH ASPIRIN, British Journal of Surgery, 80(6), 1993, pp. 723-724
Aspirin induces a haemorrhagic diathesis that persists for at least 1
week after discontinuation of the drug. The effect of the vasopressin
analogue desmopressin was studied in 12 patients treated with aspirin
who were undergoing cholecystectomy. Desmopressin was given to six of
these patients. There were five postoperative bleeding complications;
all occurred in patients who had not received desmopressin (P < 0.05).
The bleeding time was prolonged in aspirin-treated patients and norma
lized by desmopressin (P < 0.05). Desmopressin can be used safely to p
revent bleeding induced by aspirin.