ERYTHEMA MULTIFORME-LIKE ERUPTION IN ASSOCIATION WITH SEVERE HEADACHEFOLLOWING PYRITINOL

A 46-year-old woman presented with an unusual erythema multiforme-like eruption and severe headache 10 days after treatment with pyritinol f or cerebral concussion. Histopathologic findings were consistent with erythema multiforme. Skin lesions and headache cleared after withdrawa l of the drug. According to neurological examination and magnetic reso nance imaging of the brain, the headache may have resulted from a slig ht, pyritinol-induced vasculitis. Previous reports on severe pyritinol -induced side effects and possible pathogenetic mechanisms are reviewe d. Since pyritinol cannot be considered as an essential drug for cereb ral concussion, adverse effects as described here raise doubts as to i ts general use in the given indication.