ANTI-MLS(A)-LIKE EFFECT OF CBA J ANTI DBA(2) ANTIBODY IN INVITRO MLRSBETWEEN MLS INCOMPATIBLE COMBINATIONS/

Antisera from CBA/J (H-2k,Mls(a)) mice hyperimmunised with DBA2 (H-2(d ),MlS(a) ) and/or AKR (H-2k,MlS(a)) splenocytes, can block in vitro ML Rs against Mls(a) determinants. These two anti-sera are furthermore sp ecifically cytotoxic against targets expressing H-2 components but not against MlS(a)-bearing targets. In these experimental models the anti -MlS(a)-like effects of CBA/J anti-DBA2 and CBA/J anti AKR antibodies seem to be associated with an autoreactive immune response in CBA/J mi ce elicited by DBA2 and AKR splenocytes, respectively. In this report we propose that anti-Mls(a) antibodies can also be generated in a situ ation in which MlS(a) is presented as 'altered self' in conjunction wi th allo-determinants.