PHARMACOLOGICAL PROPERTIES AND TOXICOLOGY OF MED-15, A PRODRUG OF TOLMETIN

Authors
CARUSO A CUTULI VMC DEBERNARDIS E ATTAGUILE G AMICOROXAS M
Citation
A. Caruso et al., PHARMACOLOGICAL PROPERTIES AND TOXICOLOGY OF MED-15, A PRODRUG OF TOLMETIN, Drugs under experimental and clinical research, 18(11-12), 1992, pp. 481-485
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drugs under experimental and clinical research → ACNP
ISSN journal
03786501
Volume
18
Issue
11-12
Year of publication
1992
Pages
481 - 485
Database
ISI
SICI code
0378-6501(1992)18:11-12<481:PPATOM>2.0.ZU;2-U
Abstract
In this study the pharmacological evaluation of MED-15, a non-acidic p rodrug of tolmetin, is described. After oral administration the new co mpound shows a marked anti-inflammatory activity similar to that of to lmetin, but with minor ulcerogenic action and lower acute toxicity.