EFFECTS OF KETOPROFEN (NSAID) ON THE PHARMACOKINETICS OF PEFLOXACIN AND OFLOXACIN IN HEALTHY-VOLUNTEERS

The influence of ketoprofen (K), a non steroidal antiinflammatory drug (NSAID) on the pharmacokinetics of two fluoroquinolone derivatives: o floxacin (O) and pefloxacin (P) was studied in ten healthy adult male volunteers. AH subjects orally received every 12 h the fluoroquinolone derivative (either O or P) for three days and the combination of the quinolone and ketoprofen (once a day) during the three following days. Two pharmacokinetic studies were performed for each quinolone, on day s four and eight of the treatment. Blood samples were taken at times 0 , 1, 2, 3, 4, 6, 8, 10, 12 and 24 h after dosing. Urine was collected during 4 time-periods: 0-4 h, 4 -8 h, 8-12 h and 12-24 h. Plasma and u rine concentrations of the active drug of O and P were measured by mic robiological assay. Ketoprofen did not significantly modify the pharma cokinetic parameters of the two fluoroquinolones studied in terms of p eak plasma levels, time to peak, area under the curve, elimination hal f-life, volume of distribution and total and renal clearances.