GAS-CHROMATOGRAPHIC SEPARATION OF DIASTEREOISOMERIC AND ENANTIOMERIC FORMS OF SOME FLUORINATED AMINO-ACIDS ON GLASS-CAPILLARY COLUMNS

The monofluorinated analogues of 2-aminocarboxylic acids up to C-7 wer e efficiently separated into the diastereomers on glass capillary colu mns coated with achiral phases BP-1, BP-10 and OV-330. In addition, so me difluoro and trifluoro analogues were also measured. Chiral resolut ion was achieved on capillary well-coated open tubular fused-silica co lumns coated with chiral phases XE-60-L-Val-L-(1-phenylethyl)amide, Ch irasil-L-Val and Behenoyl-L-Val-tert.-butylamide. The separation facto rs and the Kovats indices of the fluorinated amino acids were determin ed and compared. The erythro racemates display a higher degree of reso lution than the threo ones. The order of elution was found to be the L - after the D-solute on all L-phases.