EFFECT OF ANTI-TNF-ALPHA TREATMENT IN AN ANTIBIOTIC TREATED MURINE MODEL OF SHOCK DUE TO STREPTOCOCCUS-PYOGENES

Experimentally, Gram-negative septic shock can be prevented by the pro phylactic use of an anti-TNF-alpha monoclonal antibody. The clinical s imilarity between Gram-negative and Gram-positive septic shock suggest ed that anti-TNF-alpha therapy might have a wide application. Increase d levels of TNF-alpha were seen in a murine model of septic shock due to Streptococcus pyogenes but administration of an anti-TNF-alpha mono clonal antibody had no beneficial effect on the outcome.