EFFECTS OF CHRONIC DESIPRAMINE ADMINISTRATION ON THE LOCUS-CERULEUS NEURONAL-ACTIVITY IN THE LEARNED HELPLESSNESS PARADIGM

Authors
PAVCOVICH LA RAMIREZ OA
Citation
La. Pavcovich et Oa. Ramirez, EFFECTS OF CHRONIC DESIPRAMINE ADMINISTRATION ON THE LOCUS-CERULEUS NEURONAL-ACTIVITY IN THE LEARNED HELPLESSNESS PARADIGM, Brain research bulletin, 32(2), 1993, pp. 83-86
Citations number
38
Categorie Soggetti
Neurosciences
Journal title
Brain research bulletin → ACNP
ISSN journal
03619230
Volume
32
Issue
2
Year of publication
1993
Pages
83 - 86
Database
ISI
SICI code
0361-9230(1993)32:2<83:EOCDAO>2.0.ZU;2-G
Abstract
One week after inescapable shock (IS) exposure, animals showed an incr eased number of escape failures in the shuttlebox and a decreased nora drenergic (NA) transmission. The latter was assessed by electric activ ity of locus coeruleus (LC) neurons. Seven daily injections of desipra mine (DMI) were effective in reducing the number of escapes failures i n the shuttlebox, but such treatment did not modify the decreased elec tric activity of LC NA neurons observed 7 days after IS. These results are discussed in terms of the action of DMI on NA terminals in revers ing the behavioral deficit induced by IS.