S. Nicolaidis et Z. Desainthilaire, NONAMPHETAMINE AWAKENING AGENT MODAFINIL INDUCES FEEDING CHANGES IN THE RAT, Brain research bulletin, 32(2), 1993, pp. 87-90
In rats, modafinil, an alpha1 adrenergic receptor dependent, that has
been shown to increase wakefulness without subsequent rebound effect,
decreases feeding and reduces body weight. However, modafinil does not
show a monotonic dose-related decrease in food intake. The dose-respo
nse curve for modafinil is U-shaped; feeding decreases after doses of
20 and 40 mg/kg, but no effects were seen after doses of 10 and 80 mg/
kg. When feeding is resumed, no compensatory effect is seen, and body
weight remains lower during the 24-h session. The drinking-to-feeding
ratio remains unchanged, showing that modafinil has no effect on water
intake. These results are discussed with reference to the possible me
chanisms underlying the relation between sleep, feeding, and metabolis
m.