EFFECTS OF STRUCTURAL MODIFICATIONS OF ETHER LIPIDS ON ANTIPROLIFERATIVE ACTIVITY AGAINST HUMAN GLIOMA CELL-LINES

The effect of structural modifications of ether lipids on antiprolifer ative activity was studied in four human glioma cell lines. Drug poten cy, determined by microtetrazolium assay, varied 7- to 30-fold. CP 46, 665 was most potent; Amido-18-OEt was least potent. Antiproliferative activity was highly dependent on drug exposure time. Except for CP 46, 665, which reached maximal activity after 2 hr, 40 muM ether lipids we re effective only after 24 hr. Structural modifications of ether lipid s can increase their potency and reduce the time required for antiprol iferative activity. Ether lipid analogs may be useful for treating hum an gliomas.