GAMMA-RADIATION-INDUCED DIFFERENTIATION ON HUMAN NEUROBLASTOMA-CELLS IN CULTURE

Authors
ROCCHI P FERRERI AM SIMONE G GRANCHI D NANNI P FRAU A PAOLUCCI P PAOLUCCI G
Citation
P. Rocchi et al., GAMMA-RADIATION-INDUCED DIFFERENTIATION ON HUMAN NEUROBLASTOMA-CELLS IN CULTURE, Anticancer research, 13(2), 1993, pp. 419-422
Citations number
17
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
13
Issue
2
Year of publication
1993
Pages
419 - 422
Database
ISI
SICI code
0250-7005(1993)13:2<419:GDOHNI>2.0.ZU;2-A
Abstract
We have studied the effect of gamma radiation on differentiation in ne uroblastoma cell lines AF8 and SJ-N-KP. Growth inhibition and morpholo gical and biochemical differentiation have been examined following rad iation exposure to 1-10 Gy. Gamma radiation induced marked growth inhi bition and morphological differentiation in a dose-and time-dependent manner in both cell lines, and induced biochemical differentiation in AF8 cells.