THE ROLE OF T(H)1 AND T(H)2 CELLS IN A RODENT MALARIA INFECTION

Authors
TAYLORROBINSON AW PHILLIPS RS SEVERN A MONCADA S LIEW FY
Citation
Aw. Taylorrobinson et al., THE ROLE OF T(H)1 AND T(H)2 CELLS IN A RODENT MALARIA INFECTION, Science, 260(5116), 1993, pp. 1931-1934
Citations number
22
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
260
Issue
5116
Year of publication
1993
Pages
1931 - 1934
Database
ISI
SICI code
0036-8075(1993)260:5116<1931:TROTAT>2.0.ZU;2-Z
Abstract
CD4+ T cells play a major role in protective immunity against the bloo d stage of malaria, but the mechanism of protection is unclear. By ado ptive transfer of cloned T cell lines, direct evidence is provided tha t both T(H)1 and T(H)2 subsets of CD4+ T cells can protect mice agains t Plasmodium chabaudi chabaudi infection. T(H)1 cells protect by a nit ric oxide-dependent mechanism, whereas T(H)2 cells protect by the enha ncement and accelerated production of specific immunoglobulin G1 antib ody.