APPLICATION OF 2D H-1-NMR SPECTROSCOPY TO THE STUDY OF THE BRAIN, SPINAL-CORD, AND SCIATIC-NERVE

Authors
BELOEIL JC GILLET B FEDELI O BERENGER G LOMBARDI V MARZULLO F SCOZZAFAVA A
Citation
Jc. Beloeil et al., APPLICATION OF 2D H-1-NMR SPECTROSCOPY TO THE STUDY OF THE BRAIN, SPINAL-CORD, AND SCIATIC-NERVE, Molecular and chemical neuropathology, 19(1-2), 1993, pp. 1-13
Citations number
23
Categorie Soggetti
Pathology,Neurosciences
Journal title
Molecular and chemical neuropathology → ACNP
ISSN journal
10447393
Volume
19
Issue
1-2
Year of publication
1993
Pages
1 - 13
Database
ISI
SICI code
1044-7393(1993)19:1-2<1:AO2HST>2.0.ZU;2-I
Abstract
Homonuclear H-1 2D NMR spectroscopy (COSY experiments at 400 and 600 M Hz) were used to study the rat brain in vivo and the rabbit spinal cor d and sciatic nerve in vitro. The following metabolites were identifie d: lactate, alanine, threonine, GABA, glutamine/glutamate, N-acetyl as partate, aspartate, taurine, inositol derivatives, choline derivatives , and glucose. The sciatic nerve spectra showed characteristic COSY gr aphs of saturated and unsaturated fatty acids, and linoleic and linole nic type structures were identified.