DSM III-R acknowledges that delusional disorder and mood disturbance c
an coexist. The aim of the study is to analyze mood disturbances occur
ring within a delusional disorder. An external validator, as the incre
ased familial fisk of psychiatric disorder, is also added to clarify t
he relationship between the two diagnostic areas. We found a high freq
uency of mood disturbances in our patients (50.7%). We were able to id
entify a proportion of delusional patients affected by a recurrent for
m of mood disturbance (35.2%); in about 42% of these patients the onse
t of the mood disturbance preceded the onset of the delusional disorde
r by a considerable interval of time. Our hypothesis is that, in these
cases, the observed mood disturbance could represent a codiagnosis of
true mood disorder. This hypothesis is partly supported by familial d
ata.