METHOTREXATE-INDUCED BRAIN NECROSIS AND SEVERE LEUKOENCEPHALOPATHY DUE TO DISCONNECTION OF AN OMMAYA DEVICE

A 63-year old woman with breast carcinoma developed leucoencephalopath y and local brain necrosis after intraparenchymal infusion of methotre xate. This iatrogenic condition was caused by drain disconnection of t he Ommaya device (bore hole type). The diagnosis of this rare complica tion of an Ommaya device was based on multiplanar MR-imaging. The case is discussed with regard to the complications of intraventricular che motherapy by means of an Ommaya reservoir.