SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITIES OF NEW 1,4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROOXYALKYLESTER MOIETIES AT THE 3-POSITIONS AND 5-POSITIONS

Authors
OGAWA T NAKAZATO A TSUCHIDA K HATAYAMA K
Citation
T. Ogawa et al., SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITIES OF NEW 1,4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROOXYALKYLESTER MOIETIES AT THE 3-POSITIONS AND 5-POSITIONS, Chemical and Pharmaceutical Bulletin, 41(6), 1993, pp. 1049-1054
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
6
Year of publication
1993
Pages
1049 - 1054
Database
ISI
SICI code
0009-2363(1993)41:6<1049:SAAAON>2.0.ZU;2-5
Abstract
We have synthesized new 1,4-dihydropyridine derivatives having nitroox yalkylester moieties at the 3- and 5-positions in order to develop pot ent and long-lasting vasodilators. The antihypertensive activities of these compounds were compared with that of nifedipine. One of them, 2- nitrooxypropyl 3-nitrooxypropyl nitrophenyl)-1,4-dihydro-3,5-pyridined icarboxylate (CD-349) was selected for further development. The struct ure-activity relationship is discussed.