STRUCTURE-ACTIVITY STUDY OF ANTIHYPERTENSIVE 1,4-DIHYDROPYRIDINE DERIVATIVES HAVING NITROOXYALKYL MOIETIES AT THE 3 AND 5 POSITIONS

1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as e sters at the 3 and 5 position possess antihypertensive activity. To un derstand how substituents affect the biological activity, the quantita tive structure-activity relationship (QSAR) of 27 compounds was analyz ed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR m odels suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4-dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensi ve activity.