COATING OF PHARMACEUTICAL POWDERS BY FLUIDIZED-BED PROCESS .5. AGGLOMERATION AND EFFICIENCY IN THE COATING WITH AQUEOUS LATICES OF COPOLY(ETHYL ACRYLATE-METHYL METHACRYLATE-2-HYDROXYETHYL METHACRYLATE)

Authors
ICHIKAWA H JONO K TOKUMITSU H FUKUDA T FUKUMORI Y
Citation
H. Ichikawa et al., COATING OF PHARMACEUTICAL POWDERS BY FLUIDIZED-BED PROCESS .5. AGGLOMERATION AND EFFICIENCY IN THE COATING WITH AQUEOUS LATICES OF COPOLY(ETHYL ACRYLATE-METHYL METHACRYLATE-2-HYDROXYETHYL METHACRYLATE), Chemical and Pharmaceutical Bulletin, 41(6), 1993, pp. 1132-1136
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
6
Year of publication
1993
Pages
1132 - 1136
Database
ISI
SICI code
0009-2363(1993)41:6<1132:COPPBF>2.0.ZU;2-2
Abstract
The latices of copoly(ethyl acrylate-methyl methacrylate-2-hydroxyethy l methacrylate) exhibited a very low degree of agglomeration in the Wu rster coating process, when the softening temperatures of their films were higher than inlet air temperature. This low agglomeration was due to their poor film-formability and, consequently, their low binding s trength. Although this led to a low fixing efficiency of cosuspended s olid particles, the coating efficiency of polymer itself remained high (about 90%). This low tendency of agglomeration was confirmed even in a coating of as fine a powder as 32-44 mum.