SYNTHESIS OF PERFRAGILIN B, A CYTOTOXIC ISOQUINOLINE QUINONE ISOLATEDFROM THE BRYOZOAN MEMBRANIPORA-PERFRAGILIS

Authors
PARK A SCHMITZ FJ
Citation
A. Park et Fj. Schmitz, SYNTHESIS OF PERFRAGILIN B, A CYTOTOXIC ISOQUINOLINE QUINONE ISOLATEDFROM THE BRYOZOAN MEMBRANIPORA-PERFRAGILIS, Tetrahedron letters, 34(25), 1993, pp. 3983-3984
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
25
Year of publication
1993
Pages
3983 - 3984
Database
ISI
SICI code
0040-4039(1993)34:25<3983:SOPBAC>2.0.ZU;2-0
Abstract
The cytotoxic isoquinoline quinone perfragilin B (2), which was isolat ed from the bryozoan Membranipora perfragilis, has been synthesized. T he key step involves a Diels-Alder reaction between a substituted 2-az abutadiene (4) and 2,3-bis(thiomethyl)-1,4-benzoquinone (6) to produce the isoquinoline skeleton.