THE ISOLATION AND ABSOLUTE-CONFIGURATION OF (1S, 2S, 3R)-4-HYDROXYMETHYLCYCLOPENT-4-ENE-1,2,3-TRIOL - A PUTATIVE INTERMEDIATE IN THE BIOSYNTHESIS OF ARISTEROMYCIN BY STREPTOMYCES-CITRICOLOR

Authors
ROBERTS SM THORPE AJ TURNER NJ BLOWS WM BUSS AD DAWSON MJ NOBLE D RUDD BAM SIDEBOTTOM PJ WALL WF
Citation
Sm. Roberts et al., THE ISOLATION AND ABSOLUTE-CONFIGURATION OF (1S, 2S, 3R)-4-HYDROXYMETHYLCYCLOPENT-4-ENE-1,2,3-TRIOL - A PUTATIVE INTERMEDIATE IN THE BIOSYNTHESIS OF ARISTEROMYCIN BY STREPTOMYCES-CITRICOLOR, Tetrahedron letters, 34(25), 1993, pp. 4083-4086
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
25
Year of publication
1993
Pages
4083 - 4086
Database
ISI
SICI code
0040-4039(1993)34:25<4083:TIAAO(>2.0.ZU;2-T
Abstract
The novel tetrol 5 has been isolated from cultures of Streptomyces cit ricolor and shown to have the absolute configuration 1S,2S,3R. Additio n of 5 to an aristeromycin non-producing mutant of S. citricolor suppo rted production of both aristeromycin 1 and neplanocin A 2, suggesting that 5 is an intermediate on the biosynthetic pathway.