Rr. Kuske et al., BREAST-CONSERVATION THERAPY FOR INTRADUCTAL CARCINOMA OF THE BREAST, International journal of radiation oncology, biology, physics, 26(3), 1993, pp. 391-396
Citations number
26
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: Between 1979 and 1987, 76 women with 77 ductal carcinomas in-
situ of the breast were evaluated by The Radiation Oncology Center aft
er breast conservation surgery. Methods and Materials: Seventy breasts
(91%) had tylectomy and irradiation and seven breasts (9%) had tylect
omy alone. Median follow-up was 4.0 years, with a range of 2-10 years.
Fifty patients (65%) had occult lesions discovered by mammography wit
h a median mammographic size of 0.9 cm. The twenty-six patients with p
resenting symptoms had a median clinical tumor size of 1.95 cm. All pa
tients had local excision of the primary tumor. Of 15 patients who had
axillary dissections, one had nodal metastasis. Seventy breasts were
irradiated. Seven patients refused radiotherapy. Results: Overall 5-ye
ar actuarial survival was 99%; 5-year actuarial disease-free survival
was 89%; the 5-year actuarial intramammary tumor control rate for irra
diated patients was 93% vs. 57% for patients not irradiated (p < 0.001
). Comedocarcinoma had a 5-year actuarial tumor control rate of 75%, 8
8% in the irradiated group as compared to 98% for all other histologic
subtypes of ductal carcinoma in situ (p < 0.03). All six patients wit
h local failure were successfully salvaged by further surgery. Multiva
riate analysis revealed significant factors in local control to be (a)
radiotherapy, (b) comedocarcinoma histology, and (c) menopausal statu
s. Conclusions: Although the number of patients treated is small, and
follow-up time is limited, these early results support the contention
that the treatment of ductal carcinoma in situ by excision and irradia
tion is an acceptable alternative to mastectomy. We urge caution in tr
eating patients with the comedocarcinoms subtype and counsel these pat
ients to have more treatment than excision alone.