TISSUE DISTRIBUTION OF CIS-DIAMMINEDICHLOROPLATINUM(II) FOLLOWING INTRAPERITONEAL ADMINISTRATION TO PATIENTS WITH RECURRENT GASTRIC-CANCER

Using atomic absorption spectrophotometry, we determined the concentra tion of platinum in tissues obtained at autopsy of 4 patients with rec urrent gastric cancer. Patients had been given intraperitoneal cis-dia mminedichloroplatinum(II) (cisplatin, CDDP). There was no correlation between the concentration of platinum and the dose of CDDP. Platinum w as distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatmen t of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.