INDUCTION OF HEPATOCELLULAR CARCINOMAS IN THE EGYPTIAN TOAD BUFO-REGULARIS BY AN ANTIFUNGAL DRUG (GRISEOFULVIN)

Authors
ELMOFTY MM KHUDOLEY VV ESSAWY AE ABDELKERIM HM
Citation
Mm. Elmofty et al., INDUCTION OF HEPATOCELLULAR CARCINOMAS IN THE EGYPTIAN TOAD BUFO-REGULARIS BY AN ANTIFUNGAL DRUG (GRISEOFULVIN), Oncology, 50(4), 1993, pp. 267-269
Citations number
21
Categorie Soggetti
Oncology
Journal title
Oncology → ACNP
ISSN journal
00302414
Volume
50
Issue
4
Year of publication
1993
Pages
267 - 269
Database
ISI
SICI code
0030-2414(1993)50:4<267:IOHCIT>2.0.ZU;2-1
Abstract
Neoplastic lesions(hepatocellular carcinomas) were induced in the live r in 18 of 100 experimental toads (Bufo regularis) force fed with the antifungal drug griseofulvin, at a dose level of 0.4 mg/50 g every day . Maximal time of exposure and observation was 12 weeks. The first tum ors appeared in 2 male toads 4 weeks after the initiation of feeding.