CHIRAL PRECURSORS OF OPTICALLY-ACTIVE JUVENOIDS

Authors
ZAREVUCKA M REJZEK M WIMMER Z SAMAN D STREINZ L
Citation
M. Zarevucka et al., CHIRAL PRECURSORS OF OPTICALLY-ACTIVE JUVENOIDS, Tetrahedron, 49(24), 1993, pp. 5305-5314
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
24
Year of publication
1993
Pages
5305 - 5314
Database
ISI
SICI code
0040-4020(1993)49:24<5305:CPOOJ>2.0.ZU;2-F
Abstract
For preparation of all four enantiomers of 2-(4-hydroxybenzyl)-1-cyclo hexanol (1a-4a) by biotransformation reactions, Saccharomyces cerevisi ae (SC) and pig pancreatic lipase (PPL) were used in aqueous media. Th e THP-protected substrates (5b, 6b and 7b) gave products with a good e nantiomeric excess comparable with that of the CH3-protected substrate s (5c,6c and 7c), whereas the deprotection was much easier in case of the THP-protected compounds.