EFFECTS OF SOME CEPHALOSPORINS AND TEICOPLANIN ON PLATELET-AGGREGATION

Antibiotics may interfere with platelet (PLT) function, and beta-lacta m antibiotics may interact with PLT aggregation, by inhibiting the bin ding of agonists of this aggregation (such as ADP and collagen) to spe cific receptor sites. In this study we have evaluated the relative in- vitro antiplatelet effects of some old and new cephalosporins (cefonic id, ceftazidime, ceftriaxone, cefotaxime, cefuroxime and flomoxef) and of teicoplanin, a new glycopeptide antibiotic. All the cephalosporins tested, and also teicoplanin, were found to have the potential to adv ersely affect human platelet aggregation only at high concentrations w hich are not achieved in vivo.