Since 1979 acetylcholinesterase has been used in clinical practice for
motorsensory differentiation. It was first used for median and ulnar
nerve injuries at the wrist. Recently the application was extended to
secondary nerve repair, including plexus reconstruction. The aim of th
is study was to present, for the first time, clinical results of motor
sensory differentiated median and ulnar nerve repair and to show the a
dvantage of this method in secondary, repair. We compared a group of n
ine patients with motorsensory differentiated median and ulnar nerve r
epair with a group of 13 patients without motorsensory differentiation
. Sensibility testing, strength measurements, and anatomical examinati
ons were performed. The hand function was expressed in percentage valu
es. Compound muscle action potentials and sensory antidromic conductio
n velocities were measured electroneurographically. Sensibility recove
ry was significantly better after motorsensory differentiated median n
erve repair (P < 0.05). In secondary nerve repair acetylcholinesterase
was used additionally for evaluating the level of resection of the pr
oximal stump. The time required for perioperative histochemical differ
entiation has now been reduced to 2 hr.