INHIBITING EFFECTS OF SEROTONIN AND SEROTONIN ANTAGONISTS ON THE MIGRATION OF MONONUCLEAR LEUKOCYTES

Authors
BONDESSON L NORDLIND K LIDEN S SUNDSTROM E
Citation
L. Bondesson et al., INHIBITING EFFECTS OF SEROTONIN AND SEROTONIN ANTAGONISTS ON THE MIGRATION OF MONONUCLEAR LEUKOCYTES, Immunopharmacology and immunotoxicology, 15(2-3), 1993, pp. 243-250
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Immunopharmacology and immunotoxicology → ACNP
ISSN journal
08923973
Volume
15
Issue
2-3
Year of publication
1993
Pages
243 - 250
Database
ISI
SICI code
0892-3973(1993)15:2-3<243:IEOSAS>2.0.ZU;2-J
Abstract
The effect of serotonin and the serotonin antagonists ketanserin, meth iotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mono nuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10( -10) mol/l. An inhibition of the mononuclear leucocyte migration was a lso caused by ICS-205-930 at 10(-4) mol/l, ketanserin at 10(-4) and 10 (-8)-10(-10) mol/l and methiotepine at 10(-4) and 10(-6)-10(-8) mol/l. No inhibiting effects of serotonin br the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both ser otonin and serotonin antagonists may inhibit mononuclear leucocyte mig ration.