PENILE INTRAEPITHELIAL NEOPLASIA - CLINICAL PRESENTATION AND AN ANALYSIS OF THE PHYSICAL STATE OF HUMAN PAPILLOMAVIRUS DNA

Forty-four men with penile intraepithelial neoplasia (PIN) and a match ed control group of 88 men with condyloma acuminatum were evaluated in three centers studying anogenital human papillomavirus (HPV) infectio ns. PIN and condyloma groups could not be distinguished on the basis o f historical features or clinical presentation. Although PINs were mor e likely than condylomata to be pigmented (31/46 [67%] vs. 33/97 [34%] , P < .001), 43% of PIN III were not pigmented, suggesting that pigmen tation is not a sensitive indicator of high-grade PIN. HPV-16 infectio n, as determined by in situ hybridization, was closely associated with PIN III (0/24 PIN I contained HPV-16 vs. 12/13 PIN III, P < .001). So uthern blot analysis demonstrated only episomal viral genomes, suggest ing that integration is not an early event in penile neoplasia.