To compare AIDS-defining conditions in women and men, US adult AIDS ca
ses diagnosed between January 1988 and June 1991 and reported to the C
enters for Disease Control and Prevention through June 1992 were exami
ned. For most AIDS-defining conditions, the prevalence was similar for
women and men when differences in race/ethnicity and mode of transmis
sion were accounted for. Pneumocystis carinii pneumonia was the most p
revalent condition (>50%) regardless of gender, race/ethnicity, or mod
e of transmission. By logistic regression analysis, among injection dr
ug users, conditions reported significantly more frequently in women t
han in men include esophageal candidiasis (odds ratio [OR], 1.51; 95%
confidence interval [CI], 1.40-1.62), herpes simplex virus (HSV) disea
se (OR, 1.68; CI, 1.46-1.94), and cytomegalovirus (CMV) disease (OR, 1
.43; CI, 1.18-1.73). More knowledge of the interrelationships in women
between HIV infection and secondary opportunistic infections, includi
ng candidiasis and sexually transmitted diseases (e.g., HSV and CMV) i
s needed.