Cw. Wyble et al., INTRACRANIAL HEMORRHAGE AS THE SYNERGISTIC EFFECT OF UROKINASE AND RENAL DYSFUNCTION - A CASE-REPORT, Vascular surgery, 27(5), 1993, pp. 395-399
This case report details a patient treated for a gangrenous toe by ang
ioplasty, sympathectomy, and aortobifemoral grafting who arrived at th
e hospital with acute renal dysfunction and an occluded bypass graft.
The patient had no abnormal results from coagulation studies and no ab
solute contraindications to urokinase therapy but died from intracrani
al hemorrhage. The authors believe that hemostatic system impairments
related to renal dysfunction act synergistically with thrombolytic age
nts to produce abnormal bleeding. This case report suggests a synergis
tic interaction between acute renal dysfunction and urokinase therapy.