INTERACTING HOBO TRANSPOSONS IN AN INBRED STRAIN AND INTERACTION REGULATION IN HYBRIDS OF DROSOPHILA-MELANOGASTER

Citation
Yt. Ho et al., INTERACTING HOBO TRANSPOSONS IN AN INBRED STRAIN AND INTERACTION REGULATION IN HYBRIDS OF DROSOPHILA-MELANOGASTER, Genetics, 134(3), 1993, pp. 895-908
Citations number
39
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00166731
Volume
134
Issue
3
Year of publication
1993
Pages
895 - 908
Database
ISI
SICI code
0016-6731(1993)134:3<895:IHTIAI>2.0.ZU;2-6
Abstract
A transposable hobo element in the Notch locus of the Uc-1X chromosome , which does not interfere with the normal expression of the locus, in teracts with other hobo elements in the same X chromosome to produce N otch mutations. Almost all of these mutations are associated with defi ciencies, inversions or other rearrangements, and hobo elements are pr esent at each of the breakpoints. The Uc-1 X chromosome produces the N otch mutations at a rate of 4-8% in both sexes of flies in a strain th at has been inbred for 96 generations. At least two-thirds of the muta tions are produced in clusters suggesting that they have originated in mitotic (premeiotic) germ cells of the Uc-1 inbred strain. The intera ction of hobo elements in the Uc-1 X chromosome can be repressed by at least two different mechanisms. One found in three inbred strains not related to the Uc-1 strain involves a maternal effect that is not att ributable to the actions or products of hobo elements. Repression by t his mechanism is manifested by a clear reciprocal cross effect so that the production of Notch mutations is repressed in the daughters of Uc -1 males, but not in the daughters of Uc-1 females. The other mechanis m apparently requires genetic factors and/or hobo elements in a partic ular strain of Oregon-R; complete repression is present in both types of hybrids between Uc-1 and this strain.