11Q AND CONSTITUTIONAL X-TRISOMY IN A PATIENT WITH M5B ACUTE NONLYMPHOCYTIC LEUKEMIA

Authors
BIGAZZI C GALIENI P SCARINCI R VIVARELLI R BUCALOSSI A BIANCOLINI G FALBO R VESSICHELLI F DISPENSA E
Citation
C. Bigazzi et al., 11Q AND CONSTITUTIONAL X-TRISOMY IN A PATIENT WITH M5B ACUTE NONLYMPHOCYTIC LEUKEMIA, Haematologica, 78(3), 1993, pp. 185-186
Citations number
21
Categorie Soggetti
Hematology
Journal title
Haematologica → ACNP
ISSN journal
03906078
Volume
78
Issue
3
Year of publication
1993
Pages
185 - 186
Database
ISI
SICI code
0390-6078(1993)78:3<185:1ACXIA>2.0.ZU;2-Z
Abstract
A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subse quently, two courses of chemotherapy for resistant ANLL were administe red without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of he matological neoplasia has not been described.